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Aglycosylated antibodies and antibody fragments produced in a scalable in vitro transcription-translation system

Simulations of M8891 PK and associated PD in humans were conducted by integrating predicted human PK parameters into the preclinical PK/PD model

The prepared tissue sections and cells were blocked with 5% BSA for 30 min and then incubated at 4C overnight with the following primary antibodies: MAP-2 (1:500, Abcam, United States), Ace-tubulin (1:500, Cell Signaling Technologies, United States), Tyr-tubulin (1:500, Sigma Aldrich, United States), GRP78 (1:1000, Abcam, United States), and MBP (1:500, Cell Signaling Technologies, United States)