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3), which is known to upregulate the expression of genes involved in amino acid transport or synthesis, one-carbon metabolism, and glutathione biosynthesis 33,34 (Fig

While there is no exact time these products have to be taken, we recommend taking them in the morning and/or early afternoon

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Clinical implications of persister biology Although drug-tolerant persister cells are now well established in experimental melanoma models, their direct targeting in the clinic remains challenging due to their transient, non-genetic, and phenotypically heterogeneous nature