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[DOI] [PubMed] [Google Scholar] 63.Mittal D, Gubin MM, Schreiber RD, Smyth MJ

Furthermore, Endo-Exos exert a dual destructive effect in endothelial injury: they not only serve as carriers to synergistically transport matrix metalloproteinases (such as MMP-2 and MMP-9), directly enzymatically degrading vascular basement membrane components (90), but also target and inhibit mTOR kinase via the pathogenic miR-99a/b they are enriched with, driving sustained inflammatory responses during sepsis (91)