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K.JensenB

Biometals 32 , 343353 (2019)

Additionally, GTCs activate the Nrf2/ARE antioxidant signaling pathway by promoting Nrf2 nuclear translocation, upregulating heme oxygenase-1 (HO-1) expression, and downregulating Kelch-like epoxychloropropane-1-protein (Keap1) expression ( The primary active component of Centella asiatica (L.) Urb., hydroxyasiaticoside (2 mg/kg/day, administered for 14 days), exhibits significant multi-target neuroprotective effects in a rotenone-induced PD rat model