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Description

American Journal of Clinical Nutrition 48, 1988, 1451-1462

as the Site Management Organization for the clinical trial

P.McGeeB.LiangT.ChandlerK.TayarachakulS.et al (2017)

HIF-1 can activate PDK1 (phosphatidylinositol-dependent protein kinase 1), which can then phosphorylate and inhibit pyruvate dehydrogenase (PDH) E1[130], thus inhibiting acetyl coenzyme A synthesis, and blocking the TCA cycle and thereby freeing pyruvate from mitochondrial OXPHOS