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The authors suggest that saturation of these enzymes is unlikely to occur with normal human dietary patterns, perhaps explaining the relative stability of muscle carnosine over time (42)

While a high carbohydrate meal can lead to an increase in oxidative stress, and caloric intake of lipids that exceeds energy expenditure leads to high production of ROS, essential fatty acids (EFAs) of the omega-3 family, in contrast to other lipids, play a defensive role from oxidative stress (270, 271) Eating fibre-rich foods may protect against oxidative stress, slightly improving the indices of inflammation and oxidative stress (272)

These defects reveal the centrality of zinc-dependent enzymatic maturation in Golgi-mediated protein quality control