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It provides broader context for Dihexa's mechanism of action and its position within the angiotensin IV receptor research field, evaluating both the strength and limitations of the existing preclinical evidence base

[1] [2] While feeling cold is not listed as a direct adverse effect in the FDA prescribing information, some patients report increased cold sensitivity during treatment

Almeida RC, Souza DG, Soletti RC, Lpez MG, Rodrigues AL, Gabilan NH (2006) Involvement of PKA, MAPK/ERK and CaMKII, but not PKC in the acute antidepressant-like effect of memantine in mice

With no placebo control behind any community report, expectation effects cannot be separated from any drug effect