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Fibrosis Hepatic fibrosis represents an early pathological state of the liver, wherein the activation of hepatic stellate cells (HSCs) constitutes the cornerstone of the fibrogenic process [222, 223]

TNF--induced necroptosis causes damage to cerebral endothelial cells in blood vessels, neuroinflammation, and dysregulation of astrocyte Kir4.1 [108, 109]

Fer-1 has also been found to inhibit ROS/RNS, attenuating rotenone-induced -synuclein aggregation in dopaminergic SH-SY5Y cells (Kabiraj et al., 2015), thereby reversing MPTP-triggered behavioral deficits in a mouse model of PD and protecting the neurons ( 3.2 Alzheimers disease Alzheimers disease (AD) is marked by the gradual deterioration of neurons within the CNS