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2023;15:e43111

Despite the stereotypes of drug-seeking behaviors and narratives of illicit opioid use dominating the public perception of the opioid epidemic, the fact remains that a sizable portion of people who develop opioid use disorder start using opioids because of a medical prescription

However, compared with Cys, Sec has higher nucleophilicity [24], oxidation susceptibility, and acidity, which is mainly reflected in its relatively lower pKa (5.2) [25,26]