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(6) Once a cohort of 80 animals (including 40 animals receiving NMN) had tumours that reached 60160 mm 3 in size, animals were randomly sorted into receiving either doxorubicin, cisplatin or vehicle control, for six groups (ctrl, doxorubicin, cisplatin, NMN alone, doxorubicin with NMN, cisplatin with NMN) with 10 animals in each group

A NF-B-independent function of NIK has also been demonstrated in hepatocytes, in which it promotes insulin resistance and lipid accumulation in a mouse model of metabolic nonalcoholic steatohepatitis (NASH)

The following data were extracted in addition to the previously mentioned outcomes: digital object identifier, first author, publication year, countries, centers, study period, study population, sepsis definition, age, gender, PCT protocol, protocol adherence, appropriateness of AB therapy, and exclusion criteria

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