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Reduced levels of frataxin in FRDA patients are associated with defects of iron-sulfur cluster (ISC) biosynthesis (Bradley et al., 2000), mitochondrial iron accumulation in heart and dentate nucleus (Foury and Cazzalini, 1997

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His physical therapy program consisted of a Pilates program, a non-weight bearing to weight-bearing strength program and specific stretching

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However, more recent studies are limited ( GKT136901 and GKT137831 can inhibit NOX-1, NOX-4, and NOX-5 activities

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