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These signaling cascades produce tissue-specific effects: hepatic IGF-1 production for endocrine growth signaling, muscle protein synthesis and glucose uptake, adipose tissue lipolysis, bone formation, and immune cell modulation

This often occurs in smokers, people with metabolic disease, heavy alcohol drinkers, as a side effect of certain prescription drugs, rheumatoid arthritis and impaired thyroid function

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MOTS-c activates AMPK pathways to improve insulin sensitivity, mitochondrial function, and metabolic flexibility