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Beyond these established mechanisms, emerging, yet still limited, evidence suggests that glycine may also produce depolarizing effects via glycine-activated excitatory receptors (eGlyRs), including GluN1/GluN3-containing NMDA receptor assemblies that can be activated by glycine in a glutamate-independent manner

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Tiopronin is structurally similar to the GPx1 cofactor glutathione and was observed to align in a similar orientation to glutathione in the active site of GPx1 in the bovine model

Focusing on the use of chemical tools that target ferroptosis in preclinical studies, we also summarize recent advances in targeting ferroptosis across the growing spectrum of ferroptosis-associated pathogenic conditions