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Given continuous exposure to luminal antigens, the intestinal barrier plays a critical regulatory role by selectively permitting the passage of essential molecules while restricting the translocation of potentially harmful compounds [7]

Under prolonged injury, inflammation, or mechanical stress, fibroblasts can phenotypically transform into myofibroblasts characterized by -SMA expression, synthesis of collagen-rich ECM, and fibroblast proliferation (88)

doi: 10.1016/0026-0495(77)90088-9 [DOI] [PubMed] [Google Scholar] 151.Luo Y, Kawashima A, Ishido Y, Yoshihara A, Oda K, Hiroi N, et al