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Patients are told directly that HA is a symptom-management treatment, not a cure, that responses vary, and that HA may need to be topped up over time to maintain the benefit

This means that the ability of the transplanted cells to produce and secrete the correct matrix components is insufficient for long-term function, as the biomechanically indispensable architectural structures are difficult to form 56

Anemia prevents the body from producing sufficient red blood cells

[] Several mitochondrial-targeted therapeutic strategies are currently under clinical investigation for cardiovascular diseases, reflecting a shift toward addressing metabolic impairments at the cellular level [Table 1]