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In the case of the C677T variant, it is the letter C

A screening guide was developed prior to the initial screening to train all reviewers on the eligibility criteria (protocol CRD420251088025 in PROSPERO)

Discussion Disorders in melanin formation have been linked to various skin diseases in humans such as hyperpigmentation and skin cancer

In this scenario, greater LC3-II content with combination treatment relative to the test compounds alone is indicative of increased flux through the autophagy process, while a lack of effect of the combo treatment compared to compound alone may suggest a blockade of the process