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Translational advances to date have been most pronounced for a defined subset of actionable heterogeneity features, including (i) truncal oncogenic drivers and convergent resistance mutations, (ii) tumor immune contexture, (particularly inflamed versus immune-excluded states), (iii) myeloid-mediated immunosuppressive niches within the tumor microenvironment, as a modifiable resistance axis, (iv) epigenetic and phenotypic plasticity that supports reversible drug-tolerant states, and (v) spatially organized hypoxic and stromal niches that influence drug delivery and immune accessibility

The consistent observations indicating a role for glutathione metabolism in autism spectrum disorders highlight the potential role of glutathione in them

It is important for both patients and prescribers to understand that while glutathione suppositories can provide therapeutic benefits, they should be used as part of a comprehensive treatment plan

J Clin Invest 125 (4): 15911602