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[PubMed: 23348842] (Controlled trial of kava [60-120 mg kavalactones twice daily] vs placebo for 6 weeks in 58 patients with generalized anxiety disorder found no change in ALT levels or other liver tests in either group)

doi: 10.1016/j.jaad.2012.03.036 145

This microbiota-metabolite-target organ regulatory paradigm provides new perspectives for understanding the mechanisms of action of natural active compounds