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For example, in pulmonary MVECs exposed to chronic IH, ROS production increased and was associated with endothelial barrier dysfunction due to ROS-dependent activation of extracellular signal-regulated kinases (ERK) 1/2 and c-Jun N-terminal kinases that initiate the reorganization of cytoskeletal and junctional proteins [154]

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Available from: [DOI] [PMC free article] [PubMed] [Google Scholar] 452.Wiesman AI, Madge V, Fon EA, Dagher A, Collins DL, Baillet S PREVENT-AD Research Group