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doi: 10.1016/j.lwt.2016.06.029 15 de SimoneC

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Its mechanism relies on spatiotemporal coordination among epidermal cells, immune cells, and fibroblasts through extracellular matrix (ECM) remodeling and signaling factor cascades, involving multi-dimensional molecular interaction networks such as gene expression regulation, metabolic reprogramming, and microenvironmental homeostasis