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Lastly, lifestyle-integrated approaches, such as time-restricted eating (TRE) combined with low-dose antioxidants, may amplify endogenous defenses while minimizing pharmacological risks (Varady et al., 2022)

First, there is considerable heterogeneity in study designs, including wide variations in the dosage, bioavailability, and treatment duration of supplements (e.g., -3 PUFAs, collagen peptides), which complicates direct comparison and meta-analysis

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After absorption, SCFAs are directly transported to the liver via the portal vein where they can be converted into endogenous molecules such as cholesterol, fatty acids, and glucose, or function as signaling molecules (van der Beek et al., 2015)