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25 In a 2012 study of adults aged 45 and older in the Chongming District of Shanghai, the prevalence of NAFLD and MAFLD (based on 2020 criteria) was 36.9% and 40.3%, respectively

Rhythmic daily oscillations in both circulating innate and adaptive immune cells, and in cytokine and chemokines occur in the healthy brain (Labrecque and Cermakian, 2015), and circadian clock disruptions dysregulate immune response (Comas et al., 2017) and alters circulating proinflammatory cytokines, complement factors, and oxidative stress (Shivshankar et al., 2020)

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Vizuete J, Camero A, Malakouti M, Garapati K, Gutierrez J