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It is also clear from the above table that both natural and newly synthesized substances inhibit Ferroptosis and thus repair SCI mainly by affecting xCT, GSH, GPX4, FSP1, and Nrf2 factors (Table 1)

This distinction suggests that early DDAVP administration in the proactive group might have facilitated controlled sodium correction once the underlying causes of hyponatremia were addressed, often eliminating the need for further doses on the second day, contrasting with the reactive approach where DDAVP administration was based on evolving sodium levels, potentially leading to later interventions

Detailed clustering analysis of the expression patterns indicated predominant expression of genes carrying NF-B response elements

No recent clinical trials have been conducted with other metal-based drugs