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doi: 10.1038/ncb3346 58 PrantyA

Methods: Two unrelated female patients, both out of consanguineous unions, were evaluated clinically, radiologically and genetically for progressive neurological symptoms

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Second, a slower and long lasting (seconds) Ca 2+ elevation contributes to a prolonged blood vessel dilation (Lind et al., 2+ can lag a few seconds arteriolar dilation supports the hypothesis that astrocytic Ca 2+ -dependent mechanisms may not be a prerequisite for CBF response initiation (Nizar et al., 2013)