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administration of ketotifen can suppress the itching.23 We should bear in mind that localized itching can be a warning for the development of medullary tumors or tumors of the central nervous system,24,25 and so it is a relevant symptom in patients with NF1

2019;98(37): e17095

Mohammed et al., 2021), and reduced mortality (Campbell et al., 2018)

Abbreviations ABA: Abscisic acid ACO: ACC-oxidase ACC: 1-Aminocyclopropane-1-carboxylic acid ALMTs: Aluminum-activated malate transporters AMADH: Aminoaldehyde dehydrogenase APX: Ascorbate peroxidase CAT: Catalase cGMP: Cyclic guanosine monophosphate CK: Cytokinin CKX: Cytokinin oxidase/dehydrogenase DAO: Diamine oxidase GABA: Gamma-aminobutyric acid GABA-T: Gamma-aminobutyric acid aminotransferase GAD: Glutamic acid decarboxylase GBH: Gamma-hydroxybutyric acid GDH: Glutamate decarboxylase GLYR: Glyoxylate reductase IAA: Indole-3-acetic acid IPT: Isopentenyl transferase LAT: Low-affinity GABA transporter MAPK: Mitogen-activated protein kinase MDA: Malondialdehyde PAO: Polyamine oxidase