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For instance, although temozolomide can cross the BBB and is therefore commonly employed in clinics to treat gliomas, the response rate of this treatment is only approximately 40% of patients owing to the expression of O6-methylguanine DNA methyltransferase 18 and even goes down to 20% for those suffering from higher-grade gliomas 19

C., Horton, J., Davis, T

Uncommon residues in VKDPs at the three key sites are indicated by red letter, with those known to affect propeptide binding in bold

Cioffi CL, Liu XQ, Kosinski PA, Garay M, Bowen BR (2003) Differential regulation of HIF-1 prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells