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The Groupe dEtudes Thrapeutiques des Affections Inflammatoires Digestives

Recent studies emphasize that overexpression alone does not fully explain metabolic resistance as factors including allelic variation, gene duplication, and interactions with co-factors like cytochrome P450 reductase (CPR) and cytochrome b5 (CYB5) also influence enzymatic activity and resistance intensity [194]

Cells were cultured in suspension at 37 C with 5% CO and were passaged every 23 days to be in exponential growth, keeping cell density at 0.21 10 cells/ml