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They are best viewed as part of a broader treatment plan that may include: Physical therapy Activity modification Home exercises Anti-inflammatory strategies Other regenerative or orthopedic treatments when appropriate Repeated steroid injections should also be used carefully, as excessive use may affect tendon and cartilage health over time

PMID 22450609

PKA phosphorylation of PLIN1 releases ABHD5 to fully activate PNPLA2 (12, 16) and phosphorylation of HSL promotes HSL translocation from the cytosol to LDs (88, 89) to interact with PLIN1(15, 88, 90, 91) and increases its hydrolase activity for TAGs and DAGs (92) (Figure 2)