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Description

No clonal selection was carried out to prevent single clone artefacts

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Succinate deposition increases HIF-1 stability, epigenetic alterations, and IL-1 synthesis by suppressing -ketoglutarate-dependent enzymes (Loftus and Finlay 2016)

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Long-term safety data for high-dose supplementation in healthy aging populations remains limited

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however, the current evidence base is constrained by notable limitations

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