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From there, it can be absorbed into the bloodstream, contributing to systemic levels as well

Senescence limits fibrosis 2 and cancer initiation 3 , maintains normal tissue function 4 and contributes to the outcome of many anticancer therapies 5,6

11 It has been suggested that perhaps the role of the innate immune system, as mediated by the natural killer (NK) and natural killer T cells (NKT) which are abundant in hepatocytes, is to cause the release of pro-inflammatory cytokines and chemokines that enhance hepatocellular cytotoxicity

Typically, NRF-1 expression is reduced in diabetic and high glucose conditions, with its increase often associated with therapy-induced metabolic recovery (Ding et al