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For GSTs, the protective role toward cytotoxicity or mutagenicity has been shown for many xenobiotics, including environmental carcinogens, such as polycyclic aromatic hydrocarbons (Tashiro et al., 2001) and cisplatin (Peklak-Scott et al., 2008), and hepatotoxic drugs such as diclofenac (Tolosa et al., 2017)