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Results showed that, regardless of corticosteroid combination, the doxycycline group achieved higher fever resolution rates at 24 and 48 hours than the minocycline group, and that the combination of newer-generation tetracyclines with corticosteroids significantly improved clinical symptoms, accelerated clinical and chest radiographic recovery, and prevented disease progression and complications (216)

The concentrations of both fractions were determined by precolumn derivation with 6-aminoquinolyl-N-hydroxy succinimidyl carbamate and liquid chromatography-tandem mass spectrometry (LC-MS/MS)