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Previous studies have established that the CDKN2A gene is frequently mutated in tumor suppressors and checkpoint mediators in HPV-negative HNSCC ( + T cells, follicular helper T cells, and M1 macrophages (Padhi et al., 2017)

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Antioxidants Antioxidants, mainly vitamin E, have been proposed as adjunctive treatment

From a bioindication perspective, it has been also emphasized that the determination of concentrations in both the liver and kidney, rather than in the liver alone, may increase the likelihood of identifying cases of poisoning or high exposure to certain elements, for example, lead (Wayland et al