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CRE acts as a transcription factor of different cAMP-regulated genes, including the pituitary-specific positive transcription factor 1 ( pit-1 ), which in turn stimulates the expression of GH gene ( Figure 2 ) (15, 31, 3739)

These free radicals can damage other cellular structures such as proteins, lipids, and DNA

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While elevated MMA blood concentration is considered the specific indicator of deficiency (19), other clinical assays are often used as biomarkers of vitamin B 12 status sometimes in combination