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The C-CRD of Yap1 consists of a leucine-rich export signal (NES) and two cysteine-rich domains (CRD) positioned at the N- and C-termini

These include frequent or prolonged exposure to sunlight, genetic predisposition, and hormonal fluctuations, especially those related to pregnancy or hormonal therapies, all of which can increase melanin production

[268] It is envisaged that the composition of the invention might comprise, in addition to the polypeptide of the invention defined herein, further biologically active agents, depending on the intended use of the composition

Amongst the established chemotherapeutic agents, metallodrugs have been extensively used for cancer therapy where they offer versatile electronic and unique structural features [3,4,5]