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Interestingly, both in vitro and in vivo studies report that V-type and the adjacent C1-type domains are able to form structural and functional VC1 tandem unit with multiple binding sites to recognize numerous different RAGE ligands (8789)

Flora SJ, Bhattacharya R, Vijayaraghavan R

thus, these findings should be regarded as exploratory and require validation using laser-capture microdissection or single-cell approaches to account for follicular heterogeneity