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Among Ser-GSTs, only those belonging to the Phi, Tau, and Theta classes are able to catalyze such reactions, peroxisomal GSTTs being likely specialized in the reduction of fatty acid peroxides (Dixon et al., 2009)

Potential side effects include: Injection site reactions, including redness, swelling, bruising, pain, or irritation Mild fluid retention (edema) Joint or muscle discomfort Headache, dizziness, or flushing Changes in glucose regulation, particularly in individuals with diabetes or prediabetes Itching, restlessness, drowsiness, nausea, or difficulty swallowing (3) Importantly, the occurrence of potential side effects does not predict an individual's overall response to therapy

The importance of pH should not be viewed alone but as part of a larger picture which includes the concentrations of minerals and metals, electrical conductivity, oxygen concentration, and temperature

The interplay between serotonin and the HPA axis, which is often dysregulated in individuals with depression, further adds to the complexity of how ethanol-induced changes in serotonin signaling can contribute to mood disorders (Correia and Vale 2024