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Structural optimization research focuses on understanding molecular determinants of peptide efficacy and selectivity through detailed protein-protein interaction studies

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R 3 and R 4 are independently selected from the group consisting of: hydrogen, C1-C12 alkyl, C1-C12 substituted alkyl, C1-C12 alkenyl, C1-C12 substituted alkenyl, C1-C12 alkynyl, C1-C12 substituted alkynyl, C3-C8 cycloalkyl, C3-C8 substituted cycloalkyl, C6-C10 aryl, C6-C10 substituted aryl, C3-C8 heterocycloalkyl, C3-C8 substituted heterocycloalkyl, C4-C10 heteroaryl, C4-C10 substituted heteroaryl, ^CH(R a )OPO(OY) 2 , ^CH(R a )OPO(OY)(OH) and 3 and R 4 together are bonded to form a fused bicyclic ring system or a spirocyclic ring system