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No receptor-mediated adverse events (e.g., cardiovascular effects, endocrine disruption) have been reported, consistent with NNMT's limited expression outside metabolic tissues

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Curcumin supplementation has been shown to restore brain-derived neurotrophic factor (BDNF) levels while regulating monoaminergic neurotransmission and mitigating multiple pathological processes including oxidative stress, neuroinflammation, -amyloid aggregation, tau pathology, and aluminum-induced neurotoxicity in both Alzheimers disease and depression models (Haider et al., 2015)

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