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First, the integrity of paranode, which anchors the myelin to the axolemma and forms a diffusion barrier in the paranodal region, may be disrupted with aging (Sugiyama et al., 2002)

Conflict of interests The authors have no conflict of interests to declare

The Glutathione Index (GSH/GSSG) is the best measure of antioxidant status Also, it is the amount of spent or oxidised glutathione (GSSG) that reflects to extent of oxidative stress a person is under