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In the context of viral infections, influenza virus can infect alveolar macrophages, leading to persistent inflammation, reduced phagocytic function, mitochondrial damage, metabolic alterations, and potentially even the macrophage disappearance reaction (258)

Ferroptosis, by contrast, is a distinct form of PCD driven by iron-dependent lipid peroxidation, leading to membrane damage and cell death (7)

This weakens zonules, leading to bilateral lens dislocation in most cases, prevalent from infancy to later years

The half maximal inhibitory concentration (IC50) of zebularine is approximately seven-fold higher than that of 5AC (120 M vs 17.4 M, respectively) in human bladder cancer T24 cells, with a degradation rate lower than 7% within 48 h ( Zebularine also inhibits cytidine deaminase, which confers resistance to nucleoside analogs (Zhang et al., 2021) and liver HepG2 (Zhou et al., 2011)