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Description

Common endpoints studied: Body weight change Nitrogen retention / protein synthesis Tissuespecific response Metabolic readouts (contextdependent) Dosing Protocol (Research context) Research Protocol (InVivo) Most Citable Structures A) Continuous infusion model (7 days): 0.9 mg/kg/day des(13) IGF1 7 days (osmotic minipump)

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For a diabetes follow-up, that might be home glucose readings and adherence

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Preclinical tissue models

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In mouse studies, measurable effects on organ function appeared within 10-14 days of treatment initiation

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