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Furthermore, deletion of Rtt109, the main acetyltransferase targeting this residue, shortens yeast lifespan, an effect also observed when deleting the H3K56-associated deacetylases Hst3 and Hst4 ( H3K79 H3K79, just like other lysine residues, can exist in one of three possible methylated forms: mono, di or trimethylated, which are involved in many cellular pathways, including transcription regulation, telomeric silencing, cell-cycle checkpoint, DNA repair, and cellular development (Rhie et al., 2013), mutating the lysine residue into glutamic acid (H3K79E) has an evident reduction in replicative lifespan (Sen et al., 2015)

doi: 10.1681/asn.2012070718 7 McCulloughKPMorgensternHSaranRHermanWHRobinsonBM

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