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IAV infection has also been shown to suppress glucose-6-phosphate dehydrogenase expression, leading to decreased Nrf2 expression, induction of oxidative stress, and viral replication 70

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The presence of large, conserved stem loops and reports that 3X is a poor NS5B template in vitro 27 make it a potential target for unwinding by the NS3 helicase, thereby enabling initiation of NS5B-mediated () strand synthesis