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Microglia activation increases the amount of nuclear factor kappa-light-chain-enhancer of activated B-cells (NFKB) and NLR family pyrin domain-containing 3 (NLRP3), with subsequent upregulation of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase and cytokines such as interleukin-1 beta (IL-1B) and tumor necrosis factor alpha (TNF) (53, 54)

The autonomic nervous system dysfunction may be manifested as papillary abnormalities, an abnormal reaction to histamine test, abnormal sweating, orthostatic hypotension, and disturbances of the heart rate

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Initially, your liver will focus on repairing minor damage and reducing inflammation