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These are in-vitro and preclinical laboratory observations only

Additionally, research has shown that statins can enhance eNOS activity by decreasing the expression of the membrane protein caveolin-1, thereby disrupting its binding with endothelial eNOS in caveolae (Suh et al., 2010)

Innovative Food Science & Emerging Technologies, 60 , Article 102281

Therefore, the study suggests that the mechanism by which tesofensine reduces food intake in obese rats is related to its ability to indirectly stimulate alpha-1 adrenoceptors and dopamine D1 receptors in the brain