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The rationale for combining them is based on mechanistic complementarity (non-overlapping pathways), individual safety profiles, and clinical observations from practitioners administering the combination

Ipamorelin is a selective secretagogue, meaning it has a much lower impact on hunger than other peptides like GHRP-6

However, results can vary depending on the individual

Remarkably, at this higher dose (240 g three times a day), the mean reduction in body weight with pramlintide treatment over 16 weeks was approximately twice that previously observed over a similar time-frame in insulin-treated subjects with type 2 diabetes who were treated with lower pramlintide doses (120 g)