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6 Limitation and future research priorities Despite the promising potential of ferroptosis-targeting therapies, several limitations currently hinder their translation into clinical practice

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Briefly, CLOCK and BMAL1 heterodimerize and activate transcription of Period (Per)1 / 2 (PER), Cryptochrome (Cry)1 / 2 (CRY), and other clock controlled genes (CCGs) via E-box or E-boxlike elements in their promoter regions