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In the Phase 2 retatrutide trial ( Jastreboff et al., NEJM 2023 ), body-composition imaging showed fat mass falling substantially more than lean mass, meaning the majority of the weight lost was fat

The trial was conducted in accordance with the Declaration of Helsinki (1996 revision) and under the principals of good clinical practice, as laid out in the International Conference on Harmonization document Good Clinical Practice Consolidated Guideline

This approach was chosen because clinical cutoffs are based on disease-related epidemiological data and biomarkers unrelated to fertility

How Common is Vitamin B12 Deficiency and When is a Blood Test Needed