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As of early 2026, multiple Phase 3 trials have reported positive topline results, regulatory submissions have been filed, and the FDA is reviewing orforglipron for an obesity indication with a target action date of April 10, 2026

JCI Insight 2:e90133

As such, while preclinical evidence supports the hypothesis that exercise can regulate oxidative stress and HPA axis function, the extent to which these findings can be generalized to human populations is still waiting to be investigated